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Clinical Trials: Obstetrics and Gynecology
IRB No. 11-168-1 (Dr. Lawrence Engmann, PI): A Prospective Comparison of Transcriptional Profiling of Luteal Phase Endometrial Biopsies After Ovarian Stimulation with Gonadotropins and Induction of Oocyte Maturation with a Gonadotropin Releasing Hormone (GnRH) Agonist or Human Chorionic Gonadotropins (hCG)
The purpose of the study is to compare gene expression profiles in endometrial biopsies taken during the window of implantation after triggers of oocyte maturation using GnRH agonist or hCG. The hypothesis is that the reduced rate of embryo implantation in some women triggered with GnRH agonist is due to alter gene expression in the endometrium.