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24-099J-1
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Intra-placental Gene Therapy with Ad-IGF-1 in BPH/5 mice with Mesenteric Uterine Artery Branch Ligation and Association of Pre-eclampsia and IUGR
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Dr. Timothy Crombleholme
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Pre-eclampsia and hypertensive disorders of pregnancy present major health impact to both mother and fetus. Pre-eclampsia has been linked to maternal multi-organ failure, coagulopathic processes and in fetuses can impact fetal growth leading to growth restriction. The onset of pre-eclampsia is variable but typically onset is after 20 weeks of gestation. However, more severe forms of pre-eclampsia may present with earlier onset and have been linked to more egregious pregnancy complications, such as severe infantile uterine growth restriction (IUGR). Understanding the key mechanisms surrounding pre-eclampsia pathophysiology are vital to helping prevent and or cure this disease. Prior research has shown that the IGF-1 pathway is central in fetal growth and placental development. This project aims to study the pathophysiology of pre-eclampsia by studying the interrelation of IGF-1, a known common maternal and fetal pathway involved in cellular homeostasis. We will enroll mothers with pre-eclampsia, fetal growth restriction
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Obstetrics and Gynecology
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Check with study contact
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Makayla Murphy. Telephone: 860-679-3331. Email: makmurphy@uchc.edu
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Enrolling/recruiting. For current recruitment status, please check with study contact.
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