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25-198-2
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Xenobiotic transfer of semaglutide using an ex vivo placental perfusion model: a pilot study
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Dr. Andrea Shields
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To our knowledge, there are limited studies that have researched if semaglutide has an effect on the placenta or if there is considerable transfer of the drug from maternal to fetal circulation. We propose studying the transfer of the drug on a single placental lobule of 7 placentas. We hypothesize that given the large molecular composition of semaglutide there will be minimal transfer of the drug in the ex-vivo placental perfusion model, thus providing safety data on the administration of semaglutide for therapeutic indications especially during pregnancy. The specific aims are: 1) To set up and troubleshoot the placental perfusion model using 3-5 placental lobules 2) To measure and compare the levels of therapeutic semaglutide in the maternal versus fetal perfusate collected from an ex-vivo placental perfusion model.
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Obstetrics and Gynecology
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Check with study contact
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Makayla Murphy. Telephone: 860-679-3331. Email: makmurphy@uchc.edu
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Enrolling/recruiting. For current recruitment status, please check with study contact.
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