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IRB No. 16-055-2 (Dr. David Steffens, PI): Department of Psychiatry: Adult Repository

The purpose of the repository is to prospectively collect biological samples along with clinical data to facilitate future research studies and pilot analysis related to medical and behavioral health research.

IRB No. 22-255-2 (Dr. Zhichao Fan, PI): Mechanisms and Roles of Integrin Activation of Cystic Fibrosis Leukocytes

The immune system is the body';s defense against infectious organisms and other invaders. Integrins are key mediators in immunity for the recruitment of white cells which play critical roles in inflammatory diseases. Insights about Integrin function hold out the prospect of improved disease prevention and drug discovery. Integrin molecules stick to body surfaces or cells. They are vital to the successful functioning of the inflammatory response at the source of an insult. In response to inflammation or infection, white cells stick to nearby blood vessels and then crawl along the surface until they can squeeze out of the blood vessel into tissues where they must act. Studying and super imaging these mechanisms and the roles of integrin during this activation will bring new insights about leukocyte recruitment and leukocyte immune functions as well as invite discovery of novel treatments for infectious and inflammatory diseases. This project is investigating how integrins may also affect blood vessels as commonly seen in human heart disease.

IRB No. 23-134-2 (Dr. Julie Robison, PI): UConn Pepper Center (OAIC) Recruitment Volunteer Registry

Objective/Goals: The Research Volunteer Registry (RVR) is a mailing list that is used to invite and share opportunities to participate in future research studies and to community educational events the UConn Pepper Center will host.

IRB No. 23-212-2 (Dr. Mina Boutrous, PI): Effects of Socioeconomic Disparities on the Long-term Outcomes of Hemodialysis Access

Goal This project is designed to contribute institutional data to a multi-institutional registry to evaluate the impact of socioeconomic disparities on the long-term outcomes of hemodialysis access, including the choice of access modality that the patient recieve, the long term patency of hemodialysis access and their access to healthcare services overall. Specific Objectives To determine the most prevalent type of access that patients from disadvantageous socioeconomic background receive. Hypothesis: Patients from the H-ADI group are likely to have lower overall long term survival in comparison to patients from the L-ADI group. Primary Endpoint: Patient survival over time. Hypothesis: Patients from the H-ADI group are likely to have higher prevalence of hemodialysis catheter placement as well as longer total duration of the catheter in comparison to patients from the L-ADI group. Primary Endpoint: Prevalence of hemodialysis catheter placement in both groups as well as total duration (in days) of catheter dependence in both groups prior to successful use of AVF/AVG. To determine long term survival of hemodialysis access patients in both groups Hypothesis: Patients in the H-ADI group will likely have lower fistula maturation rates as well as functional patency rates at 1 and 3 years in comparison to the patients in the L-ADI group. Primary Endpoint: Fistula maturation rate Secondary Endpoints: Number of procedures to attain maturity; functional patency at 1 and 3 years To determine the prevalence of hemodialysis catheter, use in both groups and compare total duration of catheter placement. Hypothesis: Patients from the highest quantile ADI score (those at the highest level of socioeconomic deprivation) are more likely to receive AVG as opposed to AVF. Primary Endpoint: Type of hemodialysis access in the highest quintile (H-ADI) vs the lowest four quintiles (L-ADI) To examine the outcomes and overall patency of hemodialysis access in patients of the highest quintile (H-ADI) vs the lowest four quintiles (L-ADI)

IRB No. 24-110-2 (Dr. Francesco Celi, PI): Exploring Treatment Experiences in Hypothyroidism Secondary to Surgery and Autoimmune Conditions

Our project seeks to understand if our current mainstay treatment for hypothyroidism (levothyroxine) is effective in treating the symptoms our patients are telling us. There have been several publications in the literature to suggest that a significant proportion of patients continue experiencing hypothyroid symptoms despite attaining normal lab values. In this study, we will utilize focus groups to discuss patient's experiences with hypothyroidism and improvements or no improvements with treatment, as well as any burdens of treatment. We will also use a validated, thyroid-specific quality of life instrument ThyPro questionnaire.