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An open resource of human induced pluripotent stem cells lines from diverse population groups
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24-023J-2
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An open resource of human induced pluripotent stem cells lines from diverse population groups
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Dr. Paul Robson
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Specific Aims 1. Establish well characterized male and female human induced pluripotent stem cell lines (iPSCs) lines from genetically diverse healthy individuals. 2. Establish clonal sublines from a subset of karyotypically normal iPSC lines and assess their capacity for differentiation and suitability for genome editing. 3. Expand and archive a selected subset of normal, pluripotent iPSC clonal sublines and perform whole genome sequencing (WGS). 4. Release selected iPSC sublines and their genome sequences for distribution to the research community on a cost-recovery basis. Design and Outcomes Participants will provide blood samples (10-15ml) at a single visit for development of iPSC lines with consent for future research use and distribution of iPSC lines to the research community and sharing of genomic data in publicly accessible databases.
Sample Size, Population, Interventions and Duration: Up to 103 self-reported healthy adult participants (both male and female) will be enrolled in the study for a single visit lasting 30 minutes. While somewhat restricted based on enrollment we will aim to recruit individuals with the following self-reported ancestry: African/African American (n=30), Latin American/Hispanic (n=20), East/Southeast Asian (n=8), South Asian (n=14), European/White (n=8), Middle Eastern (n=10), and Other (n=13) populations.
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Other
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Check with study contact
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Heather Vargas. Telephone: 860-679-1658. Email: hvargas@uchc.edu. or Sumith Abraham Varghese. Telephone: 860-679-4903. Email: abrahamvarghese@uchc.edu
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Enrolling/recruiting. For current recruitment status, please check with study contact.
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