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Circulating Caspase-3 p17 Fragment as a Novel Marker for Cardiac Apotosis
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11-157-3
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Circulating Caspase-3 p17 Fragment as a Novel Marker for Cardiac Apotosis
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Dr. Bruce Liang
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This study is an investigator initiated prospective longitudinal follow-up study with two arms (Acute STEMI subjects and Bypass surgery subjects) and collection of DNA samples. The project plans to test the hypothesis that cardiac cells undergo cell death (apoptosis) in patients during ischemic/reperfusion (I/R), and to ultimately determine the clinical significance of such cell death. By establishing the presence and importance of cardiac myocyte apoptosis the study outcomes intends to provide the rationale for developing anti-apoptotic therapy for clinically relevant I/R conditions. The research aims are to 1) Determine existence of human cardiac myocyte apoptosis under two clinically relevant ischemia/reperfusion conditions, acute ST segment elevation myocardial infarction (STEMI) with primary percutaneous coronary intervention (PCI) and cardioplegia (cardiac muscle paralysis) for bypass surgery 2) Determine the potential clinical significance of coronary and peripheral venous levels of p17 during acute STEMI with PCI and during cardioplegiaa. 68 subjects from UCHC cardiology patient base are expected to be enrolled in this study, 34 patients with anterior STEMI and 34 patients undergoing cardio-pulmonary bypass surgery. Once blood samples are obtained from each group medical records will be reviewed or follow-up calls will be made twice a year for three years to update any new cardiac events. There is no compensation to subjects participating.
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Cardiovascular (Heart, High Blood Pressure, Etc.)
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Check with study contact
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Courtney Gold. Telephone 860-679-7549. Email: cgold@uchc.edu
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Enrolling/recruiting. For current recruitment status, please check with study contact.
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