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Clinical Trial Details
Intensive Versus Standard Blood Pressure Lowering to Prevent Functional Decline in Older People
Clinical Trial ( IRB ) #: 11-155S-2
Title: Intensive Versus Standard Blood Pressure Lowering to Prevent Functional Decline in Older People
Principal Investigator: Dr. William White
Description: The goal of this single-site, prospective randomized, open-label clinical trial is to determine if lowering and maintaining 24-h ambulatory systolic BP (ABP) to = 130 mmHg (intensive control) versus 150 mmHg) who do not have unstable cardiovascular disease, congestive heart failure or history of stroke. The key primary and secondary outcomes in the trial are: 1) change from baseline in mobility parameters (self-paced walk and stance times); 2) change from baseline in cognitive function (executive function, processing speed); 3) accrual of WMH over the course of the trial (36 months) including degeneration of tissue and tissue perfusion using an MRI technology known as diffusion tensor imaging (DTI). Study subjects will be recruited over 24 months with follow-up of 36 months. Adverse events, tolerability, and health-related quality of life outcomes will be evaluated as well. Complete assessments will be performed at baseline, after 18 months and at the end of the study (36 months).
Classification:
  Cardiovascular (Heart, High Blood Pressure, Etc.)
  Hypertension/High Blood Pressure
Eligibility Criteria: Check with study contact
How to Contact: The study is closed. It is not enrolling. Please do not call about this study.
Enrollment Status/Comments: The study is closed. It is not enrolling. Please do not call about this study.
Web Address: clinicaltrials.gov/show/NCT01650402