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Clinical Trial Details
A Phase III Trial of Pelvic Radiation Therapy Versus Vaginal Cuff Brachytherapy Followed by Paclitaxel/ Carboplatin Chemotherapy in Patients with High Risk, Early Stage Endometrial Carcinoma (GOG0249)
Clinical Trial ( IRB ) #: 11-029-3
Title: A Phase III Trial of Pelvic Radiation Therapy Versus Vaginal Cuff Brachytherapy Followed by Paclitaxel/ Carboplatin Chemotherapy in Patients with High Risk, Early Stage Endometrial Carcinoma (GOG0249)
Principal Investigator: Dr. Molly Brewer
Description: The purpose of this study is to compare the effects of radiation therapy to the pelvis (SoC) with vaginal radiation therapy followed by 3 cycles of the chemotherapy drugs, paclitaxel and carboplatin in patients with high s-risk Stage I-II endometrial cancer. Additionally, this study will compare treatment groups by looking at survival, side effects and differences in location of cancer reoccurrence in patients. By evaluating blood and tumor specimens, this research study aims to determine trends that may help identify which patients may respond best to which treatments.
Classification:
  Cancer - Female Reproductive
  Women’s Health (Infertility, Menopause, Etc.)
Eligibility Criteria: Women who have high-risk early stage endometrial cancer which appears to be confined to the uterus. Endometrial cancer is commonly treated with surgery. You have already had surgery including hysterectomy (removal of the uterus), removal of the ovaries, and possibly the removal of pelvic and para-aortic lymph nodes. Following your surgery, your doctor has identified you to have risk factors related to the cancer which place you at a greater risk for the cancer coming back (recurrence).
How to Contact: Melissa Parente. Telephone: (860) 679-1144. Email: mparente@uchc.edu
Enrollment Status/Comments: No longer Enrolling/recruiting.