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Hematopoietic epigenetic memory as a driver of inflammaging
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24-127J-1
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Hematopoietic epigenetic memory as a driver of inflammaging
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Dr. George Kuchel
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This is a prospective, single-visit study. The UConn Center on Aging will recruit 80 healthy community-dwelling young (20-35 years old, n=40: 20 men, 20 women) and older adults (>65 years old, n=40: 20 men, 20 women). Blood samples (50 mL, single draw) will be collected from these participants and participants will be clinically assessed using Frailty Index, frailty phenotype and blood-borne measures of biological aging. This research is being done to determine how aging affects the rare blood stem cells that give rise to the circulating immune cells.. Scientists may conduct genomic testing of cells in blood in this research. This means that they will be looking at which genes are turned on and which are turned off in immune cells. This study may help contribute to new strategies to rejuvenate the immune system and responses.
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Aging
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Blood - Other
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Check with study contact
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Megan Wing Telephone: 860-679-8865. Email wing@uchc.edu
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Enrolling/recruiting. For current recruitment status, please check with study contact.
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