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High-resolution single cell profiling of SARS-CoV-2 vaccine responsiveness in healthy adults
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21-149J-1
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High-resolution single cell profiling of SARS-CoV-2 vaccine responsiveness in healthy adults
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Dr. George Kuchel
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This study is a collaboration between The Jackson Laboratory for Genomic Medicine (JAX) in Farmington, CT and UConn Health in Farmington, CT. All recruitment, enrollment, clinical data, and sample collection will occur at the UConn Center on Aging (COA) or at the Clinical Research Center (CRC), under the direction of Dr. George Kuchel, Professor of Medicine and Director of the UConn COA. This prospective, single-site, multi-cohort observational study is designed to determine how vaccine formulations and subject age affect immunologic responses to SARS-CoV-2 vaccine and to uncover the molecular signatures (genomics) elicited by novel COVID-19 vaccines. Up to 114 SARS-CoV-2 naïve healthy men and women aged 21 years or over, from all races and ethnic backgrounds that receive the Pfizer/Moderna/J&J COVID-19 vaccine will be enrolled to this study over a one-year period. Participation will involve nine (9) study visits for adults receiving the two-dose Pfizer or Moderna vaccine and seven (7) study visits for adults receiving the single-dose J&J vaccine. Blood samples (at all 9/7 visits) and nasal swabs (at three visits) will be collected.
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Infectious Disease/Immune System
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Viral Diseases
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1.Able and willing to provide
written informed consent
2. Male or Female, age 21 years
or older?
3. Weight 110 pounds or more?
4. Scheduled to receive FDA
Emergency Use Authorized
(EUA) mRNA-based SARS-CoV-2
(COVID-19) vaccine as part of
the Federal SARS-CoV-2
Vaccination Program.
6. Available to attend all 7 or 9
study visits around their
SARS-CoV-2 (COVID-19)
vaccination over a one-year
period
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M. Wing 860-679-8865, wing@uchc.edu
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Enrolling/recruiting.
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