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3D Microscopic Imaging to Differentiate Healthy vs Diseased Red Blood Cells
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16-210-6
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3D Microscopic Imaging to Differentiate Healthy vs Diseased Red Blood Cells
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Dr. Biree Andemariam
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This study is a prospective, clinical/translational research study using peripheral blood from consenting SCD patients and healthy control volunteers. From our earlier experiments with red blood cells using the 3D microscope, we have found that the mechanics of cell membrane fluctuations are very sensitive to the state of health of the cell. Parameters extracted from the dynamic imaging of the cell (amplitude of cell membrane fluctuation, frequency of cell membrane fluctuation, volume fluctuation and dynamic light scattering) can be used to discriminate healthy and diseased cells. The present study is aimed at collecting dynamic information of healthy versus diseased cells to quantify mechanical properties and estimate the state of health of the cells as well as the effectiveness of the developed 3D microscope in automatic identification of diseases. We hypothesize that the 3D microscope will be able to discriminate between healthy and sickle cell disease red blood cells, a tool that will have practical use in diagnosis and treatment of the disease. We will enroll both healthy and sickle cell disease adults who are 18 years of age and older who have not had a transfusion in the past 3 months.
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Blood - Sickle Cell Disease
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Rare Diseases
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Check with study contact
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Sasia-Marie Jones. Telephone: Not available. Email: sajones@uchc.edu
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Enrolling/recruiting. For current recruitment status, please check with study contact.
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