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Clinical Trials: Hypertension/High Blood Pressure
IRB No. 17-115-3.2 (Dr. Kai Chen, PI): The Risk Factors and Imaging Study of Diastolic Dysfunction
A normal heart function consists of muscle contraction during systole and muscle relaxation during diastole. Diastolic dysfunction refers to a condition in which abnormalities in mechanical function are present during diastole, namely impaired relaxation and increased stiffness. Both systolic dysfunction and diastolic dysfunction will ultimately lead to heart failure. We are specifically interested in diastolic heart failure, because the prevalence continues to rise and there is no effective therapy for this condition till today. The diagnosis of diastolic heart failure is based on echocardiographic evidence of diastolic dysfunction - signs of increased muscle stiffness and reduced relaxation. There are a number of risk factors that are believed to contribute to the development of diastoic dysfunction, including high blood pressure, diabetes and overweight. More importantly, an effective treatment of the risk factor may reverse the diastolic dysfunction. However, when diastolic heart failure is present, none of the treatment has shown the benefit. This highlights the importance of early detection and early intervention in the prevention of diastolic heart failure, by recognizing the risk factors. Therefore, the goal of this study is to identify the risk factors associated with diastolic dysfunction, by reviewing the existing chart and echocardiographic data.