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IRB No. 03-007-1 (Dr. Ernst Reichenberger, PI): Genetic Analysis of Human Disorders: Keloid Formation

The purpose of this study is to identify genes which cause or contribute to keloid formation. Keloids are wounds which grow beyond the margin of the original skin wound.

IRB No. 19-036-1 (Dr. Jun Lu, PI): Rheumatology-Dermatology Combined Clinic Patient Registry

The Rheumatology-Dermatology Combined Clinic Patient Registry is a prospective registry that collects patient data within the UConn Department of Dermatology combined clinic for patients being treated for both rheumatologic and dermatologic conditions. Both dermatologists and rheumatologists participate in care for patients suffering from connective tissue disease with both cutaneous and rheumatological manifestations. By establishing combined rheumatology-dermatology clinic, patients will receive collaborative care from both specialties in the same visit. The combined multidisciplinary clinic offers the opportunity for improving care quality, patient satisfaction, and continued education and professional development for physicians. The protocol includes patients over the age of 18 that are being treated in the UConn combined rheumatology-dermatology clinic. This registry will gather data over a 10 year period for future research regarding improving patient care, diagnosis, treatment and long term outcomes for this subspecialty clinic.

IRB No. 21-074-2 (Dr. Jun Lu, PI): Corrona Atopic Dermatitis Registry: A Study of Post Approval Drug Safety and Effectiveness

The objective of the Corrona Atopic Dermatitis (AD) Registry is to create a national cohort of patients with atopic dermatitis. Data collected will be used to extensively evaluate the effectiveness and safety of medications used to treat atopic dermatitis. This will be done through the standardized collection of patient-reported outcomes (PRO) and clinician-reported outcomes (ClinRO), and the prevalence and incidence of comorbidities and adverse events, medication utilization patterns, and patient productivity measures.Personal information is also collected from each consenting registry patient allowing for linkages to other public or private clinical and administrative databases, as well as to databases maintained by organizations focused on the care and treatment of atopic dermatitis for the purposes of clinical, market, or outcomes research. This provides an opportunity to evaluate other aspects of the disease and its treatment including but not limited to clinical and drug cost-effectiveness, healthcare resource utilization, and patient adherence.

IRB No. 24-158JO-2 (Dr. Julie Robison, PI): Skin immunity as a function of frailty, aging, and skin microbiome composition

Specific Aims AIM 1. Identify distinct and common skin immune features associated with aging and frailty-associated dysbiosis (FADS) to inform skin infection risk. AIM 2. Model how aging-related changes in skin infection response are modulated by the microbiome, senescence, inflammation, and genetic diversity. Design and Outcomes This is a prospective, observational, cohort study that will investigate how age-related declines in skin immunity relate to corresponding changes in the skin and its microbiome. Sample Size, Population, Interventions and Duration In this study, 42 participants ages 20-40 years old and 82 participants ages 60 years and older will be enrolled at the UConn Center on Aging in Farmington, CT and will participate in 2-4 study visits over 5 weeks. Visit 2 will occur the day after Visit 1. Visit 3 will occur 21 +/- 7 days after Visit 1 and Visit 4 the day after Visit 3. Skin (swab and micropatch at 7 skin sites) will be collected from participants to study the microbiome, immune profiling of interstitial fluid (ISF), and metabolomics. The seven skin sites will also be probed for skin physiologic metrics associated with frailty and aging.