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Clinical Trials: Healthy Volunteer
IRB No. 22-330S-1 (Dr. Angela Bermudez Millan, PI): Implicit Affectivity and Transition to a Plant-based Diet
This pre- and post-test study design aims to identify the impact of dietary change on mood. We will follow for three-months a sample of 30 adults that transition to a plant-based diet. The main outcome is the Implicit Positive and Negative Affect Test. Participants will complete this assessment at baseline and at 3-months. We may be able to associate dietary intake changes with changes in affect. This could help describe the underlying mechanisms that lead to depression. In doing so this study may serve to emphasize the importance of diet in managing depression risk. Specific Aim 1: To examine the change in plant and animal-based intake after transition to a plant-based diet. Specific Aim 2: To examine the change in implicit affectivity in adults after transition to a plant-based diet. Specific Aim 3: To examine the association between plant-based intake and implicit affectivity.
IRB No. 23-193J-1 (Dr. Eric Wang, PI): Healthy Control Blood Collection to Investigate Mechanisms of Leukemogenesis and Therapy Resistance
Specific Aim To collect fresh healthy human blood for use in developing and optimizing co-culture assays with human malignant cell lines upon genetic and pharmacologic perturbation of gene candidates identified for therapy resistance. In addition, we will use healthy donor specimens to perform high-throughput genomic analyses compared to our human leukemia cell lines and use the leftover specimens as healthy controls for future research projects. Design and Outcomes This is a prospective, single-site study that will collect human blood specimens (50ml) from healthy adult participants Sample Size, Population, Interventions and Duration In this study, up to 20 healthy men and women participants, ages 18 and older will be enrolled at the UConn Health Clinical Research Center in Farmington, CT. Study participation will involve consent followed by a single visit lasting 30 minutes for blood and data collection.