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IRB No. 09-010-1 (Dr. Rajesh Lalla, PI): Oral Mucositis Research Registry/Repository

Oral Mucositis refers to mouth sores that occur in cancer patients due to the chemotherapy or radiation therapy that they receive. The Oral Mucositis Research studies related to oral mucositis or cancer and to identify potentially eligible subjects for future research. The Oral Mucositis Research Repository will hold in an identifiable format, any remaining tissue or blood samples or derivatives thereof for use in oral mucositis or cancer studies, at the conclusion of the study for which they were collected.

IRB No. W25-046-2 (Dr. Upendra Hegde, PI): A Randomized, Double-blind, Placebo-controlled Phase 3 Study to evaluate Dostalimab as Sequential Therapy after Chemoradiation in Participants with Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma (JADE)

The purpose of this study is to find out if an experimental drug, called dostarlimab, via 11 administrations starting shortly after chemoradiotherapy (CRT) has finished, can delay or reduce the risk of cancer returning when compared to placebo given over the same time period following CRT.