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Clinical Trials: Cancer - Female Reproductive
IRB No. 11-029-3 (Dr. Molly Brewer, PI): A Phase III Trial of Pelvic Radiation Therapy Versus Vaginal Cuff Brachytherapy Followed by Paclitaxel/ Carboplatin Chemotherapy in Patients with High Risk, Early Stage Endometrial Carcinoma (GOG0249)
The purpose of this study is to compare the effects of radiation therapy to the pelvis (SoC) with vaginal radiation therapy followed by 3 cycles of the chemotherapy drugs, paclitaxel and carboplatin in patients with high s-risk Stage I-II endometrial cancer. Additionally, this study will compare treatment groups by looking at survival, side effects and differences in location of cancer reoccurrence in patients. By evaluating blood and tumor specimens, this research study aims to determine trends that may help identify which patients may respond best to which treatments.