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Clinical Trials: Blood - Leukemia
IRB No. 01-127H-2 (Dr. Kazuya Machida, PI): Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies
Study description not available
IRB No. 17-040-2 (Dr. Jonathan Harrison, PI): Vitamin D analogs as adjuncts to chemotherapy
The purpose of this study is to gain a better understanding of how Vitamin D and similar compounds affect acute myeloid leukemia cells, and to learn if treating myeloid leukemia cells in the laboratory using Vitamin D, similar compounds, and other agents can potentially improve the outcome of treatment. Acute Myeloid Leukemia ("AML") is a cancer of white blood cells, and unfortunately, despite current best treatment, most patients diagnosed as having Acute Myeloid Leukemia die from the disease, or from its complications, within two years of diagnosis. Our research, studying AML cells from patients, suggests that treating AML using small doses of Vitamin D in combination with other agents may result in better control of the cancerous cells than using chemotherapy alone. In this research project, we wish to study precisely how Vitamin D works to improve control of AML cancer cell growth.