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IRB No. 16-055-2 (Dr. David Steffens, PI): Department of Psychiatry: Adult Repository

The purpose of the repository is to prospectively collect biological samples along with clinical data to facilitate future research studies and pilot analysis related to medical and behavioral health research.

IRB No. 21-046-2 (Dr. Kevin Manning, PI): Cognitive Remediation of Cognitive Control in Late-Life Depression

This research is being completed because depressed older adults commonly experience difficulties with concentration and processing speed, also called executive dysfunction, as well as negative affect/emotions (e.g., low mood, irritability, worry). Older adults with depression and executive dysfunction and/or negative affect/emotions regularly fail to get better with conventional antidepressant medications. Therefore, the purpose of this study is to use an established non-invasive treatment (computerized brain-training) that may improve cognitive and depression related outcomes in older adults. There are two aims of the current study. We are interested in whether a computerized braintraining treatment will improve thinking and depression in older depressed adults. We are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance imaging (MRI).

IRB No. W23-093-2 (Dr. Neha Jain, PI): An Open-label, Long-term, Safety and Efficacy Study of Aticaprant as Adjunctive Therapy in Adult and Elderly Participants With Major Depressive Disorder (MDD)

This is a clinical study of an investigational medication for adults with Major Depressive Disorder (MDD). The purpose of the study is to evaluate the effectiveness of Aticaprant when used as an add-on treatment for adults with MDD. Study participation lasts 8 weeks and includes a screening phase, a double blinded phase and a follow-up phase. There is also an optional open-label phase study for those who qualify.

IRB No. W23-227-1 (Dr. Neha Jain, PI): A Study of Disease Characteristics and Real-life Standard of Care Effectiveness in Patients with Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including an SSRI or SNRI.

This is an observational study for adults with Major Depressive Disorder (MDD). The purpose of this study is to collect information on participants’ well-being and how depression treatments help over the course of their study participation. No study medication is used in this observational study. Participants will continue to take their current medications as prescribed by their provider(s).

IRB No. W24-025-2 (Dr. Andrew Winokur, PI): A Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as an Adjunctive Treatment for Major Depressive Disorder (RELIGHT)

This is a clinical study of an investigational medication for adults with Major Depressive Disorder (MDD). The purpose of the study is to evaluate the effectiveness of REL-1017 when used as an add-on treatment for adults with MDD. Study participation lasts 8 weeks and includes a screening phase, a double blinded phase and a follow-up phase.

IRB No. U23-210-2 (Dr. Jayesh Kamath, PI): A Randomized, Double-Blind, Placebo-controlled Multicenter Study to Assess the Efficacy and Safety of Lumateperone as Adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder.

This is a clinical study of an investigational medication for adults with Major Depressive Disorder (MDD). The purpose of the study is to evaluate the effectiveness of Lumateprone when used as an add-on treatment for adults with MDD. Study participation lasts 8 weeks and includes a screening phase, a double blinded phase and a follow-up phase.